Single Saliva Sample Model-Informed Precision Dosing of Levofloxacin for Multidrug-Resistant Tuberculosis

Key Points

• The aim is to evaluate the effectiveness of a saliva sample model for dosing levofloxacin in multidrug-resistant tuberculosis treatment.
• Developed a population pharmacokinetic (popPK) model
• Utilized single saliva samples for drug concentration
• Analyzed levofloxacin exposure at a 2-hour post-dose interval
• Reliable estimation of levofloxacin levels from saliva
• Supports therapeutic drug monitoring (TDM) in routine MDR-TB care
• Provides a viable alternative to plasma-based TDM in challenging settings