Research demonstrates model-informed dosing improves levofloxacin monitoring in multidrug-resistant tuberculosis, suggesting a practical solution for care settings.
The developed popPK model enables reliable estimation of levofloxacin exposure from limited saliva samples. A single 2-h post-dose saliva concentration may support model-informed levofloxacin TDM in routine MDR-TB care. This approach may be beneficial in settings where plasma-based TDM is logistically or ethically challenging.
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Nguyen et al. (2026) studied this question.
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