Identifying the most effective components of a physical activity intervention for adults with knee replacement: the MOST Energized! study protocol

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Key Points

This trial aims to identify which supplemental components enhance physical activity levels in adults following total knee replacement.
Study design with factorial setup
336 adults who had TKR at least 12 months ago
Participants receive 6-month automated online exercise program
Random assignment to receive 0-4 non-automated intervention components
Assessment at baseline, 3 months, 6 months, and 12 months
Measured change in moderate-vigorous physical activity using accelerometers
Evaluated secondary outcomes like pain intensity and physical function
Assessed cost-effectiveness and participant engagement

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Reveals effective intervention components to increase physical activity in adults post-knee replacement, indicating need for optimized programs.

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Kennerley et al. (2026) studied this question.

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