A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets

Alessandro Cuomo; Maurizio Pompili; Antonio Vita; Edoardo Spina; Filippo Caraci; Andrea Fagiolini

doi:10.1186/s12991-026-00643-8

March 18, 2026Annals of General PsychiatryOpen Access

A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets

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Key Points

The aim is to evaluate trazodone's diverse effects as an antidepressant and its clinical applications.
Narrative review of existing literature on trazodone's efficacy and pharmacological properties.
Examination of dosing strategies and formulation types.
Review of pharmacokinetic and pharmacodynamic relationships.
Identified trazodone's broad therapeutic effects in major depressive disorder and comorbid conditions.
Highlighted the importance of tailored dosing and administration for optimal outcomes.
Outlined potential prescribing algorithms to predict patient responses.

Implication

Narrative review explores trazodone's effectiveness in managing depression and its implications for treatment enhancement.

Abstract

Trazodone is a multimodal and multifunctional antidepressant that exhibits a broad range of therapeutic effects in MDD and other comorbid conditions. Further research on the pharmacokinetic and pharmacodynamic relationship of trazodone, its parenteral use in acute settings, and the development of prescribing algorithms for predicting treatment responses may enhance its therapeutic outcomes in patients with MDD.

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Cite This Study

Cuomo et al. (2026) studied this question.

synapsesocial.com/papers/69be34af6e48c4981c672c98 https://doi.org/10.1186/s12991-026-00643-8

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A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets

Key Points

Implication

Abstract

Discussion

Cite This Study

A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets

Key Points

Implication

Abstract

Discussion

Cite This Study

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