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March 21, 2026Scientific Reports0 citationsOpen Access

Calcium-Enriched Silica/PLGA Scaffolds Enhance Bone Repair in Rabbit Model

Calcium-enriched mesoporous silica/PLGA scaffolds enhance bone repair in a rabbit femoral condylar defect model

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Authors

HWHonghan WuJWJunxi WuHTHao Tang

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Overview

In vitro and in vivo evaluations demonstrate enhanced bone repair in a rabbit model using calcium-enriched scaffolds, suggesting potential for clinical application.

Key Points

  • The aim is to evaluate the effectiveness of calcium-enriched silica/PLGA scaffolds for bone defect repair.
  • Fabricated two types of scaffolds: CMP and MP using a single-emulsion solvent evaporation method.
  • Conducted in vitro assays to assess stem cell proliferation and differentiation.
  • Established a rabbit femoral condylar defect model to evaluate scaffolds in vivo.
  • Utilized micro-CT imaging and histological staining to assess bone regeneration and biocompatibility.
  • CMP scaffolds significantly promoted mesenchymal stem cell proliferation and osteogenic differentiation compared to MP scaffolds.
  • In vivo tests showed that CMP scaffolds enhanced new bone formation and defect repair.
  • Both scaffold types demonstrated excellent tissue compatibility without adverse effects.
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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69be34f26e48c4981c6730c8https://doi.org/10.1038/s41598-026-44490-9
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