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September 10, 2025International Journal of BioprintingOpen Access

Dual-nozzle 3D-printed calcium sulfate/poly (lactic acid) scaffold with linezolid microspheres for efficient repair of femoral condyle defects in rats

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Authors

XTXiaojie TangCLChenxu LiYWYanan Wang

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Overview

Composite scaffold improves bone regeneration and infection prevention in rat cranial defects, suggesting a unique therapeutic strategy.

Key Points

  • The composite scaffold significantly enhanced bone formation by 3.2 times compared to controls, indicating effective tissue regeneration.
  • In vitro results showed that the scaffold inhibited Staphylococcus aureus activity and demonstrated excellent biocompatibility with an elastic modulus of 87 MPa.
  • The study utilized dual-nozzle 3D printing to create a calcium sulfate/poly(lactic acid) scaffold integrated with linezolid microspheres for improved outcomes.
  • This integrated approach may prevent infection-related complications, highlighting its potential for treating complex bone defects.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f847chttps://doi.org/10.36922/ijb025270269
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