482P Tumor and plasma mRNA profiling of KRAS-related genes potentially associated with outcome in KRAS G12C-mutated non-small cell lung cancer

March 17, 2026ESMO OpenOpen Access

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Key Points

The aim is to identify genetic features in KRAS G12C-mutated non-small cell lung cancer associated with outcomes.
Conducted whole exome sequencing (WES) for mutation identification.
Analyzed tumor and plasma mRNA for KRAS-related genes.
Performed immunohistochemistry (IHC) on tumor samples for protein expression validation.
Identified recurrent mutations in TP53, EGFR, and other genes.
TARP copy-number gain was significantly higher in lung adenocarcinoma with tuberculosis than in controls.
High expression of TARP and other proteins correlated with mutational features.

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Genome profiling reveals TARP amplification in KRAS G12C-mutated non-small cell lung cancer with TB, suggesting unique immune challenges.

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Rosell et al. (2026) studied this question.

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