Higher serum uric acid levels are associated with improved outcomes in acute ischemic stroke patients following intravenous thrombolysis with alteplase—a retrospective cohort study
Retrospective study finds higher serum uric acid levels improve outcomes in acute ischemic stroke patients, suggesting a potential biomarker for treatment success.
Key Points
This research investigates the relationship between serum uric acid levels and clinical outcomes in acute ischemic stroke patients treated with thrombolysis.
Retrospective analysis of acute ischemic stroke patients who received intravenous thrombolysis with alteplase.
Data collected on serum uric acid levels, demographic characteristics, and neuroimaging findings.
Primary outcome measured was a modified Rankin Scale score of 0-1 at 90 days.
Out of 130 analyzed patients, 87 achieved an excellent 90-day functional outcome (66.92%).
Patients with SUA levels >360 μmol/L had a significantly higher chance of an excellent 90-day outcome (adjusted OR: 2.690).
Higher SUA levels were also linked to a favorable outcome (mRS 0-2) with adjusted OR: 4.271.
No significant impact of SUA levels on intracranial hemorrhage or 90-day mortality was found.