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August 22, 2026BMC NeurologyOpen Access

The change in serum uric acid during hospitalization predicts short-term prognosis in patients with acute ischemic stroke: a retrospective cohort study

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Authors

AHAijie HuangXGXiaojing GuoJHJiawei He

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Overview

Retrospective cohort study reveals that changes in serum uric acid during hospitalization predict three-month outcomes in acute ischemic stroke, highlighting its potential for risk stratification.

Key Points

  • To investigate whether dynamic changes in serum uric acid (sUA) levels during hospitalization predict 3-month functional outcomes in patients with acute ischemic stroke.
  • Retrospective cohort study enrolling 555 patients diagnosed with acute ischemic stroke between January 2016 and December 2020.
  • Measured sUA at admission and pre-discharge to calculate ΔsUA, evaluating 3-month prognosis via the modified Rankin Scale (mRS).
  • Evaluated associations using univariate linear regression for continuous outcomes and binary logistic regression for binary outcomes.
  • A total of 235 of 555 patients (mean age 72.9 years, 62.2% male) experienced poor 3-month functional outcomes, with baseline sUA showing no significant difference between outcome groups.
  • Patients with good outcomes exhibited a significantly smaller decline in sUA [ΔsUA -44.9 (-91.0 to -7.0) µmol/L] compared to those with poor outcomes [ΔsUA -96.0 (-166.2 to -40.5) µmol/L].
  • Binary logistic regression established that ΔsUA during hospitalization is independently associated with 3-month prognosis.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a895f87ca7ade938187e49chttps://doi.org/10.1186/s12883-026-05300-x
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