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March 21, 2026Open Access

Anisotropic gold nanochains with dual-ligand interfaces for theranostic immune activation

CYChungmo YangKangwon National University YSYoung Ju SonKangwon National University SJSila JinKangwon National University

Key Points

Investigate the immune activation potential of anisotropic gold nanochains with dual-ligand interfaces.
Functionalization of gold nanorods with azide
Assembly of gold nanochains end-to-end
Engagement of NK cells through receptor recognition
Significantly enhanced antibody-dependent cellular cytotoxicity (ADCC) observed
ADCC enhancement is dependent on chain length

Abstract

Gold nanorods functionalized with azide assemble end-to-end into nanochains. The Fc-modified chains engage NK cells via receptor recognition, significantly enhancing antibody-dependent cellular cytotoxicity (ADCC) in a chain length-dependent manner.

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Anisotropic gold nanochains with dual-ligand interfaces for theranostic immune activation | Synapse

Cite This Study

Yang et al. (Thu,) studied this question.

synapsesocial.com/papers/69be35386e48c4981c6734a9 https://doi.org/https://doi.org/10.1039/d6ra00281a