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This framework integrates retrosynthetic planning to optimize metabolic networks, suggesting new modeling methods in synthetic biology.
Cellular metabolic pathway reconstruction is an essential yet challenging goal in synthetic biology. We outline a conceptual framework integrating retrosynthetic planning with biological constraints to enhance biological feasibility. We believe the approach spans individual- and systems-level modeling, enabling large language model-driven understanding, design, evaluation, and optimization of metabolic networks.
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Zheng et al. (2026) studied this question.
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