Resting-State EEG Microstates as Dynamic Biomarkers of Network Dysfunction and Cognitive Impairment in Patients With Multiple Sclerosis

Giorgio Leodori; Davide Maccarrone; Marco Mancuso; Maria Ilenia De Bartolo; Angelo Collura; Stefano Pellegrini; Leonardo Malimpensa; Federica Satriano; Mariangela Fratino; Daniele Belvisi; Gina Ferrazzano; Diego Centonze; Antonella Conte

doi:10.1212/wnl.0000000000214778

March 19, 2026Neurology

Resting-State EEG Microstates as Dynamic Biomarkers of Network Dysfunction and Cognitive Impairment in Patients With Multiple Sclerosis

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Key Points

The aim is to determine if EEG microstates can differentiate between patients with multiple sclerosis and healthy individuals, as well as cognitively impaired and preserved patients.
Conducted EEG microstate analysis in patients with multiple sclerosis and healthy volunteers.
Assessed cognitive function to categorize patients as cognitively impaired or cognitively preserved.
Compared EEG patterns to identify differences between groups.
EEG microstates effectively distinguished multiple sclerosis patients from healthy volunteers.
Identifiable differences in microstates were present between cognitively impaired and cognitively preserved patients.
Suggests that microstates could be dynamic biomarkers for network dysfunction.

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Implication

This investigation distinguishes cognitive impairment in multiple sclerosis patients, suggesting EEG microstates may serve as biomarkers for brain dysfunction.

Abstract

Multiple sclerosis (MS) is characterized by large-scale brain network dysfunctions. EEG microstate analysis may track these dynamics. We investigated whether microstates could distinguish patients with MS from healthy volunteers, and cognitively impaired from cognitively preserved (CP) patients.

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Cite This Study

Leodori et al. (2026) studied this question.

synapsesocial.com/papers/69be354a6e48c4981c67365b https://doi.org/10.1212/wnl.0000000000214778

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Resting-State EEG Microstates as Dynamic Biomarkers of Network Dysfunction and Cognitive Impairment in Patients With Multiple Sclerosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Resting-State EEG Microstates as Dynamic Biomarkers of Network Dysfunction and Cognitive Impairment in Patients With Multiple Sclerosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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