Why the study?
The study investigated the accommodative effects of alpha- and beta-adrenergic stimulation in human subjects.
Does instillation of hydroxyamphetamine hydrobromide and phenylephrine hydrochloride affect the response ACA ratio and accommodative amplitude in human subjects?
Does instillation of hydroxyamphetamine hydrobromide and phenylephrine hydrochloride affect the response ACA ratio and accommodative amplitude in human subjects?
Adrenergic effects on accommodation are mediated through β‐receptor sites, providing evidence for dual autonomic innervation of accommodation.
Clinicians should anticipate reduced accommodative amplitude with these agents; confirms β-receptor mediation and supports dual autonomic innervation of accommodation.
The accommodative effects of α‐ and β‐adrenergic stimulation were investigated in human subjects by measuring changes in the response ACA ratio and in the response accommodative amplitude as a result of instilling hydroxyamphetamine hydrobromide and phenylephrine hydrochloride. Statistically significant increases in the ACA ratios were found to result from hydroxyamphetamine hydrobromide, but not from phenylephrine hydrochloride. The accommodative amplitude significantly decreased under the influence of each agent. It was concluded that these adrenergic effects on accommodation were mediated through the β‐receptor sites. This provides further evidence of the dual autonomic innervation of accommodation.
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Kerry G. Stephens (1985) studied this question. Hydroxyamphetamine hydrobromide and phenylephrine hydrochloride was evaluated on Changes in the response ACA ratio and response accommodative amplitude.
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