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March 21, 2026Breast Cancer Research and Treatment2 citationsOpen Access

Omission of axillary surgery in early breast cancer with negative lymph nodes: a systematic review and meta-analysis of randomized clinical trials

BCB. B. CasteloLBL. O. BritoRTRenato Zocchio Torresan

Key Points

  • To evaluate the effects of omitting axillary surgery in early breast cancer with negative lymph nodes.
  • Conducted a systematic review and meta-analysis of randomized clinical trials
  • Analyzed outcomes related to overall survival and disease-free survival
  • Assessed rates of axillary recurrence
  • Omission of axillary surgery does not negatively affect overall survival
  • Omission does not negatively affect disease-free survival
  • There is a higher risk of axillary recurrence, but it remains low.

Abstract

The omission of axillary surgery in early-stage breast cancer with clinically negative lymph nodes does not negatively impact overall or disease-free survival. However, it is associated with a higher-though still low-risk of axillary recurrence.

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Cite This Study

Castelo et al. (2026) studied this question.

synapsesocial.com/papers/69be35606e48c4981c67399ahttps://doi.org/10.1007/s10549-026-07910-y
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