Real-world data reveals genomic alterations influencing response to PARP inhibitors in metastatic prostate cancer, suggesting biomarker testing is essential.
Most PARPi responders had alterations in HRR genes, particularly BRCA2, although some responders lacked known biomarkers associated with PARPi response. Our findings in this real-world data set support HRR gene testing for PARPi use in mCRPC and highlight the need for novel genome-wide biomarkers for patient selection.
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Chang et al. (2026) studied this question.
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