This method constructs 3-(2-allyl)-indolyl compounds using C2-defluorinative techniques, suggesting efficient synthesis pathways.
A novel method for constructing 3-(2-allyl)-indolyl substituted gem-difluoroalkenes that relies on Sc(OTf)3-catalyzed C2selective allylation/defluorination cascade of trifluoromethylated 3-indolylmethanols has been realized. This diazo-free protocol features exclusive regioselectivity and broad substrate...
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Liu et al. (2026) studied this question.
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