ABSTRACT Traditional anti‐cancer medications are severely limited in their ability to reach the tumor site because of the intricate physiological structure, microenvironment, and several physiological obstacles. A concise review on the positively charged biomolecule that is, cell‐penetrating peptides (CPPs), which are usually composed of 5–30 amino acids, can be used as molecular transporters to help therapeutic medicines pass through physiological barriers in targeting cancer cells. However, the application directed toward cancer cells is often impeded by challenges such as low specificity, rapid degradation, and inefficient intracellular delivery. Advanced positively charged biomaterials emerged as remarkable solutions to address such issues. The concise review article highlights various ways in which innovative biomaterials enhance the effectiveness of CPPs in targeting cancer cells. Strategies based on biomaterials, including nanocarriers, hydrogels, and conjugation methods, have been shown to improve the stability, specificity, and delivery efficiency of CPPs. Additionally, this review article describes the key challenges and future directions in the integration of biomaterials and CPPs for cancer therapy.
Mukta Rani (2026) studied this question.