SGK2 mediates apoptosis in herpes simplex keratitis by suppressing protective autophagy via the mTOR pathway

Suyu Liu; Yong Wang; X X Kong; Yuling Yan; Qi Wang; Feng Jang; W. C. Ye

doi:10.1186/s12985-026-03131-3

March 18, 2026Virology JournalOpen Access

SGK2 mediates apoptosis in herpes simplex keratitis by suppressing protective autophagy via the mTOR pathway

View Full Paper

Ask AI

Bookmark

Share

Key Points

To explore how SGK2 affects apoptosis in herpes simplex keratitis through the mTOR pathway.
Investigated the role of HSV-1 in modulating autophagy
Analyzed the interactions in the SGK2/TSC2/mTOR signaling axis
Examined effects on corneal epithelial cells (CECs)
SGK2 suppresses protective autophagy, leading to increased apoptosis in CECs
HSV-1 effectively manipulates this signaling pathway
Identified SGK2 as a potential target for HSV-1 treatment

Implication

Findings indicate SGK2 influences apoptosis in corneal epithelial cells, suggesting therapeutic potential against HSV-1.

Abstract

These findings indicate that HSV-1 modulates host autophagy via the SGK2/TSC2/mTOR signaling axis to induce apoptosis in CECs, suggesting SGK2 as a potential molecular target for HSV-1 therapy.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69be35a96e48c4981c674180 https://doi.org/10.1186/s12985-026-03131-3

View Full Paper

Ask AI

Bookmark

Share

SGK2 mediates apoptosis in herpes simplex keratitis by suppressing protective autophagy via the mTOR pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

SGK2 mediates apoptosis in herpes simplex keratitis by suppressing protective autophagy via the mTOR pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading