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March 21, 2026ChemBioChemOpen Access

Instant Membrane Stabilization by Damage‐Triggered Actin Polymerization in Giant Unilamellar Vesicles

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Authors

HNHuong Thanh NguyenSLSang Ho LeeCKChang Ho Kim

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Overview

This research demonstrates stabilization of membranes in giant unilamellar vesicles, indicating a novel repair mechanism.

Key Points

  • To investigate a damage-triggered mechanism for stabilizing membranes in giant unilamellar vesicles (GUVs).
  • Encapsulated ATP-activated G-actin in divalent-cation-free lumen of GUVs.
  • Supplied high concentrations of Ca2+ or Mg2+ externally to induce cation influx.
  • Induced F-actin assembly upon membrane poration to create a mechanical meshwork.
  • Localized cation entry led to rapid assembly of F-actin at membrane defects.
  • F-actin formation prevented further pore enlargement and preserved vesicle morphology.
  • Actin plug improved vesicle survival against rupture, although full impermeability was not restored.

Cite This Study

Nguyen et al. (2026) studied this question.

synapsesocial.com/papers/69be35d76e48c4981c6743f8https://doi.org/10.1002/cbic.202500974
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