Study reveals that the medial orbitofrontal cortex influences pain sensitivity and emotional behaviors, suggesting potential therapeutic targets.
The present study has revealed that the critical involvement of mOFC glutamatergic neurons in the comorbidity of chronic pain and affective disturbances. Inhibition of mOFC glutamatergic neurons attenuates both pain hypersensitivity and anxiodepressive-like behaviors after nerve injury. The discrete mOFCCaMKIIα-MD and mOFCCaMKIIα-BLA pathway independently control the sensory and affective components of neuropathic pain.
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Li et al. (2026) studied this question.
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