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April 24, 2026The Journal of Headache and PainOpen Access

Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice

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Authors

XRXiao RenXQXin-Tong QiuYLYi-Yao Li

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Overview

Investigative study reveals pathway's role in neuropathic pain and anxiety-like behaviors, suggesting therapeutic targets.

Key Points

  • This research aims to understand the role of the insular cortex to central medial thalamic nucleus pathway in pain and emotional modulation.
  • Employing neuroanatomical tracing and imaging techniques to study neuronal projections
  • Utilizing optogenetic and chemogenetic methods to manipulate neuronal activity
  • Conducting behavioral observations in a spared nerve injury mouse model for pain assessment.
  • Enhanced excitability in the dlIC-rCM pathway is linked to neuropathic pain and anxiety behaviors.
  • Activation of this pathway decreases pain thresholds and increases anxiety-like behaviors in normal mice.
  • Inhibition alleviates pain sensitivity and anxiety in SNI mice.

Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/69eb0803553a5433e34b34ddhttps://doi.org/10.1186/s10194-026-02373-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain2024 · 5 citations
  2. 2Insular balance of glutamatergic and GABAergic signaling modulates pain processing2016 · 88 citations
  3. 3Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry2021 · 40 citations
  4. 4Current Understanding of the Involvement of the Insular Cortex in Neuropathic Pain: A Narrative Review2021 · 25 citations
  5. 5Neuropathic Pain: From Mechanisms to Treatment2020 · 1,581 citations