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September 22, 2025Neurobiology of DiseaseOpen Access

Projection from the parafascicular nucleus of the thalamus to the insular cortex mediate analgesia and anti-anxiety behaviors in mice

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Authors

FLFei LiZLZiang LiJLJia Li

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Overview

Chemogenetic manipulation of the PF-IC neuronal pathway regulates analgesia and anti-anxiety in mice, suggesting a significant role in neuropathic pain.

Key Points

  • Chemogenetic activation of the PF-IC pathway alleviated hyperalgesia and anxiety-like behaviors in neuropathic mice.
  • Activation of the PF-IC neuronal pathway demonstrated analgesic and anxiolytic effects in models of nerve injury, with supporting evidence from electrophysiological activity.
  • The study utilized neuroanatomical techniques to trace projections from the parafascicular nucleus to the insular cortex.
  • Findings highlight that the PF-IC pathway's activity is suppressed under neuropathic pain conditions, indicating its potential therapeutic target.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d46fd431b076d99fa6a2d5https://doi.org/10.1016/j.nbd.2025.107107
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Also Consider

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  1. 1Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain2024 · 8 citations
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  4. 4Linking emotional valence and anxiety in a mouse insula-amygdala circuit2023 · 108 citations