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August 21, 2025Pain

Descending projections from the insular cortex to the lateral parabrachial nucleus facilitate nocifensive behaviors in rats

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Authors

YNYuka NakayaNihon UniversityKHKensuke HiroseKKKouhei KitanoNihon University

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Implication

Optogenetic stimulation increases nociceptive behaviors in rats, suggesting a role of insular cortex inputs in pain processing.

Key Points

  • Activation of insular cortex projections to the lateral parabrachial nucleus enhances nociceptive responses in rats, indicating a distinct pain pathway.
  • Behavioral tests showed increased face-wiping responses to capsaicin injection, showing a direct link to pain facilitation.
  • Analysis of neurotransmitter types indicates that glutamatergic neurons play a key role in the transmission of pain signals.
  • The research supports the hypothesis that specific neuron types in the LPBN influence the pain response, highlighting potential therapeutic targets.

Cite This Study

Nakaya et al. (2025) studied this question.

synapsesocial.com/papers/68af5418ad7bf08b1eadb509https://doi.org/10.1097/j.pain.0000000000003726
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pain Pathways and Parabrachial Circuits in the Rat2002 · 590 citations
  2. 2Autonomic responses and efferent pathways from the insular cortex in the rat1991 · 492 citations
  3. 3Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors2005 · 731 citations
  4. 4The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice2023 · 76 citations