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March 19, 2026Journal of the European Academy of Dermatology and VenereologyOpen Access

Age‐dependent reductions in natural moisturizing factor and caspase‐14 in paediatric atopic dermatitis

R. Fukuda Kyongsun Pak Hazuki Yasuda Tomoko Kawai Kenichiro Hata Naoko Mochimaru Marie Takenouchi Ryo Tanaka Rena Hashimoto Yuhki Ueda Susumu Hashimoto Keisuke SHIMAZAKI K. Yoshida

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Key Points

This research aims to investigate how age affects levels of natural moisturizing factor and caspase-14 in pediatric atopic dermatitis.
Analyzed skin samples from pediatric individuals with atopic dermatitis.
Measured levels of natural moisturizing factor and caspase-14 in the samples.
Assessed age as a variable in the expression of these biomarkers.
Natural moisturizing factor levels decrease with increasing age.
Caspase-14 levels also show age-dependent reductions.
Findings suggest a potential link between age and skin barrier function in atopic dermatitis.

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Implication

Analysis reports age-dependent reductions in skin biomarkers related to atopic dermatitis, suggesting implications for treatment.

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Cite This Study

Fukuda et al. (2026) studied this question.

synapsesocial.com/papers/69be35e66e48c4981c6746bf https://doi.org/10.1111/jdv.70417

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