Integrating experimental and theoretical approaches to unveil structure–bioactivity relationships in silver(I) N -substituted glycine complexes

Gabriela Kuzderová; Róbert Gyepes; Alan Liška; Jana Havlíčková; Mária Vilková; Simona Žiláková; Martin Kello; Tomas Pagac; Petra Olejníková; Eva Petrovova; Henrieta Matajová; Maria Kozurkova; Danica Sabolová; Michaela Rendošová; Zuzana Vargová; Ľudmila Balážová

doi:10.1039/d5dt03032c

January 1, 2026Dalton Transactions

Integrating experimental and theoretical approaches to unveil structure–bioactivity relationships in silver(I) N -substituted glycine complexes

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Key Points

The research aims to uncover the relationships between molecular structure and biological activity in silver(I) glycine complexes.
Utilized N-methyl and N-glycyl glycine derivatives as stabilizing ligands.
Conducted experimental analyses of silver(I) complexes with these ligands.
Applied theoretical approaches to evaluate structure–bioactivity relationships.
Identified specific glycine derivatives that enhance the stability of silver(I) complexes.
Demonstrated a correlation between molecular structure and biological activity.
Provided insights into the role of ligands in silver(I) complex behavior.

Implication

Experimental and theoretical analyses reveal bioactivity links in silver(I) glycine complexes, suggesting new insights on molecular interactions.

Abstract

N-methyl and N-glycyl glycine derivatives - namely (trimethylammonium)acetate (N,N,N-trimethylglycine, betaine, Bet), N,N-dimethylglycine (Dmg), N-methylglycine (sarcosine, Sar), and glycylglycylglycine (GlyGlyGly) - as naturally occurring glycine metabolites, were employed as stabilizing ligands...

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Cite This Study

Kuzderová et al. (2026) studied this question.

synapsesocial.com/papers/69be35e66e48c4981c674740 https://doi.org/10.1039/d5dt03032c

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Integrating experimental and theoretical approaches to unveil structure–bioactivity relationships in silver(I) N -substituted glycine complexes

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrating experimental and theoretical approaches to unveil structure–bioactivity relationships in silver(I) N -substituted glycine complexes

Key Points

Implication

Abstract

Discussion

Cite This Study

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