Key result
Post-COVID interstitial lung disease-associated PH linked exclusively to prolonged ICU invasive mechanical ventilation.
High BNP, impaired gas transfer, and elevated CT markers can serve as screening tools to prompt RHC referral for diagnosing post-COVID ILD-PH in patients with prior prolonged mechanical ventilation.
Supports BNP, gas transfer, and CT screening to prompt RHC after prolonged ventilation in post-COVID ILD; hypothesis-generating for PH risk.
Ten patients with post‐COVID ILD‐PH are described. This complication occurred only in patients after prolonged intensive care (ICU) admission for invasive mechanical ventilation. At the time of PH diagnosis by right heart catheterisation (RHC), all patients had high brain natriuretic peptide (BNP), impaired gas transfer at lung function testing, and elevated CT markers of PH including right to left ventricular dilatation (RV:LV ratio) and pulmonary artery to aortic ratios. Invasive haemodynamic assessment at RHC confirmed precapillary PH. These screening markers should prompt referral for echocardiography and to PH centres for consideration of RHC to confirm the diagnosis of ILD‐PH.
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Mehta et al. (2026) studied this question. Post-COVID interstitial lung disease-associated pulmonary hypertension developed exclusively in patients who required prolonged ICU admission for invasive mechanical ventilation.
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