Answers are grounded in this paper and cite their sources.
Analysis shows miconazole resistance in Malassezia pachydermatis isolates from dogs, suggesting necessary antifungal stewardship.
Clinical isolates of M. pachydermatis with reduced miconazole susceptibility were easily found, suggesting that miconazole resistance is present in routine patients. Lanosterol 14α-demethylase interactions with longer-tailed azoles involve additional contacts beyond A302 suggesting these drugs will be more effective against miconazole-resistant strains. However, effective antifungal stewardship is needed to slow development of pan-azole resistance that would limit treatment options for dogs with M. pachydermatis-associated disease.
No takes yet. Share an insight, caveat, or question.
Belcher et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: