Ultrasonographic Risk Factors for Non-Diagnostic Cytology and Malignant Histopathology in Thyroid Nodules: Results of 607 Biopsies, 138 Thyroidectomies Performed by a Single Surgeon

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Evaluate the effectiveness of ultrasound-guided fine-needle aspiration biopsy by a single surgeon, identifying risk factors for non-diagnostic results and malignancy.
Retrospective review of 607 US-FNAB procedures by a single surgeon
Analysis of histopathology from 161 nodules in 138 thyroidectomies
Correlation of nodule characteristics with Bethesda cytology categories
Non-diagnostic cytology rate was 8.73%
Anterior nodule location associated with reduced risk of non-diagnostic cytology (p=0.019)
Peripheral calcification significantly increased the risk of non-diagnostic cytology (p=0.0039)
Malignancy rates varied by Bethesda category, from 13.69% (Bethesda 2) to 100% (Bethesda 6)

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Study evaluates ultrasound-guided fine-needle aspiration outcomes in thyroid nodules, indicating specific risk factors for diagnostic challenges.

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Turan et al. (2026) studied this question.

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