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This article examines challenges in administering opioids in palliative care for chronic pain, suggesting implications for therapy selection.
This article examines organizational differences between palliative care and hospice care. The causes for these differences related to prognosis for life expectancy are outlined. Selection of optimal therapy in palliative care and hospice care is considered. The authors analyze literature data on potential problems following premature introduction of strong opioids into palliative care. The causes of higher tolerance and morphine-induced hyperalgesia following early administration of morphine in case of expected long-term survival are outlined. The role of recommendations for widespread use of strong opioids (morphine and its analogs) in hospice care is discussed.
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Palekhov et al. (2026) studied this question.
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