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Experimental findings reveal BMPR2's role in promoting odontogenic differentiation, suggesting potential gene therapy applications.
These results indicate that BMPR2 promotes odontogenic differentiation of hDPSCs by activating BMPR2-SMAD1/5/8-RUNX2 signalling, and that targeting this cascade could be a promising strategy for gene therapy in human tooth development.
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Zheng et al. (2026) studied this question.
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