Parabacteroides goldsteinii-derived outer membrane vesicles alleviate acute lung injury via modulation of bile acid metabolism

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The aim is to explore how outer membrane vesicles from Parabacteroides goldsteinii affect acute lung injury (ALI) through gut microbiome modulation.
Administered Parabacteroides goldsteinii-derived outer membrane vesicles (Pg-OMVs) to assess their effects on gut bacteria and lung inflammation.
Measured changes in the abundance of specific gut bacteria species like Akkermansia muciniphila and Clostridia_bacterium.
Analyzed systemic bile acid levels and macrophage pyroptosis activity in response to Pg-OMVs.
Increased the abundance of Akkermansia muciniphila in the gut.
Decreased the abundance of Clostridia_bacterium in the gut.
Elevated systemic bile acid (CA) levels.
Suppressed macrophage pyroptosis by inhibiting the NF-κB pathway.
Reduced pulmonary inflammation and alleviated symptoms of acute lung injury.

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A study demonstrates that outer membrane vesicles improve acute lung injury by modulating gut bacteria and inflammation.

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Zhu et al. (2026) studied this question.

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