Parabacteroides goldsteinii-derived outer membrane vesicles alleviate acute lung injury via modulation of bile acid metabolism

Key Points

• The aim is to explore how outer membrane vesicles from Parabacteroides goldsteinii affect acute lung injury (ALI) through gut microbiome modulation.
• Administered Parabacteroides goldsteinii-derived outer membrane vesicles (Pg-OMVs) to assess their effects on gut bacteria and lung inflammation.
• Measured changes in the abundance of specific gut bacteria species like Akkermansia muciniphila and Clostridia_bacterium.
• Analyzed systemic bile acid levels and macrophage pyroptosis activity in response to Pg-OMVs.
• Increased the abundance of Akkermansia muciniphila in the gut.
• Decreased the abundance of Clostridia_bacterium in the gut.
• Elevated systemic bile acid (CA) levels.
• Suppressed macrophage pyroptosis by inhibiting the NF-κB pathway.
• Reduced pulmonary inflammation and alleviated symptoms of acute lung injury.

Abstract