November 28, 2025Scientific ReportsOpen Access

Triptolide ameliorates LPS-induced acute lung injury in Balb/c mice through gut-lung axis-mediated regulation of bile acid metabolism and gut microbiota

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Authors

YZYulong Zha LFLinrui FanSecond Military Medical University TSTao Shen

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Implication

Triptolide demonstrates reduced pulmonary edema and inflammatory injury in LPS-induced acute lung injury models, indicating its role in gut microbiota regulation.

Key Points

Triptolide administration significantly reduced pulmonary edema in an acute lung injury model, enhancing lung function.
Pro-inflammatory cytokine levels decreased notably following treatment with Triptolide, reflecting reduced inflammation.
Metagenomic sequencing revealed that Triptolide alters gut microbiota composition, linking it to bile acid metabolism regulation.
These findings suggest that modulating gut microbiota may represent a valuable therapeutic strategy for acute lung injury.

Cite This Study

Zha et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a534 https://doi.org/10.1038/s41598-025-29758-w

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Implication

Triptolide demonstrates reduced pulmonary edema and inflammatory injury in LPS-induced acute lung injury models, indicating its role in gut microbiota regulation.

Triptolide ameliorates LPS-induced acute lung injury in Balb/c mice through gut-lung axis-mediated regulation of bile acid metabolism and gut microbiota

Discussion

Member takes

Implication

Key Points

Cite This Study

Triptolide ameliorates LPS-induced acute lung injury in Balb/c mice through gut-lung axis-mediated regulation of bile acid metabolism and gut microbiota

Discussion

Member takes

Implication

Key Points

Cite This Study

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