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March 21, 2026Clinical Case Reports0 citationsOpen Access

Renal‐Limited Thrombotic Microangiopathy due to Anti‐ VEGF / TKI Immunotherapy for Metastatic Renal Cell Carcinoma Presenting as Nephrotic Syndrome: A Case Report and Literature Review

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SSSB SARDARPennsylvania State UniversityAMAhmad MatarnehPennsylvania State UniversityOSOmar K. Salameh

Key Points

  • This research aims to explore the occurrence of renal-limited thrombotic microangiopathy due to anti-VEGF/TKI treatment in cancer patients.
  • Case report of a patient receiving anti-VEGF/TKI and immune checkpoint inhibitors.
  • Focus on renal complications including thrombotic microangiopathy and nephrotic syndrome.
  • Review of literature on related nephrotic disorders due to VEGF inhibition.
  • Patient developed renal-limited thrombotic microangiopathy leading to nephrotic syndrome.
  • Symptoms included significant proteinuria and hypertension related to the immunotherapy.
  • Clinical findings align with existing literature on nephrotic disorders from anti-VEGF therapy.

Abstract

ABSTRACT Vascular endothelial growth factor (VEGF) inhibition may result in proteinuria, worsening hypertension, chronic kidney injury, or glomerular disease. Recently, systemic VEGF inhibition has been reported to cause nephrotic disorders and thrombotic microangiopathy (TMA). We present a unique case of renal‐limited TMA presenting as nephrotic syndrome in a patient on anti‐VEGF/TKI immunotherapy and immune checkpoint inhibitors for metastatic renal cell carcinoma.

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Cite This Study

SARDAR et al. (2026) studied this question.

synapsesocial.com/papers/69be36bf6e48c4981c675e2bhttps://doi.org/10.1002/ccr3.72202
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