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Case report reveals nephrotic syndrome from anti-VEGF/TKI therapy in cancer patients, suggesting a rare complication.
Vascular endothelial growth factor (VEGF) inhibition may result in proteinuria, worsening hypertension, chronic kidney injury, or glomerular disease. Recently, systemic VEGF inhibition has been reported to cause nephrotic disorders and thrombotic microangiopathy (TMA). We present a unique case of renal‐limited TMA presenting as nephrotic syndrome in a patient on anti‐VEGF/TKI immunotherapy and immune checkpoint inhibitors for metastatic renal cell carcinoma.
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SARDAR et al. (2026) studied this question.
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