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Observational analysis reveals HME reduces CO2 clearance in critically ill subjects, suggesting strategies for better ventilation.
The HME impaired CO₂ elimination. Increasing VT or f to compensate for the HME-associated VD increased MP. At an equivalent minute ventilation, increasing VT was more effective for CO₂ clearance but may compromise lung protection. Under iso-CO₂ conditions, the strategies did not differ.
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Dorado et al. (2026) studied this question.
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