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The Effects of Apparatus Dead Space on P aCO 2 in Patients Receiving Lung-Protective Ventilation

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Observational study decreased PaCO2 in patients with acute lung injury, indicating optimal ventilator settings can improve gas exchange.

Investigate the impact of apparatus dead space on PaCO2 in patients receiving lung-protective ventilation.
Studied patients with acute respiratory distress syndrome/acute lung injury
Tested three different ventilator-circuit configurations for 15 minutes each
Maintained tidal volume, respiratory rate, positive end-expiratory pressure, and fraction of inspired oxygen constant
Removal of HME significantly decreased VD/VT by approximately 6% and PaCO2 by about 5 mm Hg
Further removal of flexible tubing reduced VD/VT by an additional 5% and PaCO2 by an additional 6 mm Hg
Minute ventilation decreased from 11.51 L/min to 10.35 L/min, and pH increased from 7.30 to 7.38

Hinkson et al. (2006) studied this question.

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