Intramolecular Hydrogen Bond-Driven Conformational Preferences in Pyridine Containing Dibenzamide and Dicarboxamide Derivatives: Evidence from NMR and DFT-Based Computation

Swaraj Pathak; Sandeep Kumar Mishra; Nilamoni Nath

doi:10.1039/d5cp04810a

January 1, 2026Physical Chemistry Chemical Physics

Intramolecular Hydrogen Bond-Driven Conformational Preferences in Pyridine Containing Dibenzamide and Dicarboxamide Derivatives: Evidence from NMR and DFT-Based Computation

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to explore how intramolecular hydrogen bonds influence the conformational preferences of specific pyridine derivatives.
Utilized NMR spectroscopy to analyze molecular structures and conformations.
Employed Density Functional Theory (DFT) for computational modeling of conformational behavior.
Examined both dibenzamide and dicarboxamide derivatives to assess differences in behavior.
Identified distinct conformational preferences driven by intramolecular hydrogen bonds.
Observed variations between dibenzamide and dicarboxamide derivatives in binding interactions.
Validated computational predictions with empirical NMR data.

Implication

The study investigates conformational preferences in pyridine derivatives, revealing insights into hydrogen bonding effects.

Abstract

The hydrogen bond (HB) plays a pivotal role in controlling numerous chemical and biological processes. The impact of inter- or intramolecular interactions is well established in supramolecular chemistry as well...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Pathak et al. (2026) studied this question.

synapsesocial.com/papers/69be36e36e48c4981c67615f https://doi.org/10.1039/d5cp04810a

View Full Paper

Ask AI

Bookmark

Share

Intramolecular Hydrogen Bond-Driven Conformational Preferences in Pyridine Containing Dibenzamide and Dicarboxamide Derivatives: Evidence from NMR and DFT-Based Computation

Key Points

Implication

Abstract

Discussion

Cite This Study

Intramolecular Hydrogen Bond-Driven Conformational Preferences in Pyridine Containing Dibenzamide and Dicarboxamide Derivatives: Evidence from NMR and DFT-Based Computation

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading