This research demonstrates the impact of early peptides on genetic coding rules, suggesting connections to peptide therapies.
The genetic code is best viewed as a proteome-driven, evolvable system in which early peptides actively shaped coding rules by stabilizing structure, expanding chemical diversity, and enhancing catalysis. This perspective connects origin-of-life studies with modern efforts of code expansion, translational engineering, and peptide-based therapeutics, highlighting the impact of the code's proteomic origin.
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Gustavo Caetano-Anollés (2026) studied this question.
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