This work reveals varying DNA methylation patterns linked to sex chromosomes across placental cell types, suggesting implications for pregnancy outcomes.
The lack of X-linked promoter DNAme in extraembryonic mesoderm-derived cells (endothelial/stromal) is consistent with a distinct developmental origin of these populations relative to the other placental and umbilical cell types. Autosomal DNAme also showed cell-type differences in alignment with cellular relationships observed for sex chromosomes. This work suggests the effects of sex chromosome complement on pregnancy outcomes may differ by placental cell type.
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Han et al. (2026) studied this question.
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