What question did this study set out to answer?

To characterize the timing and tissue-specific patterns of global DNA demethylation and de novo remethylation across embryonic, extraembryonic, and germline lineages during mouse development.

March 1, 1987Development

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

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Authors

MMMarilyn MonkLifeArc MBMichael Boubelı́kCzech Academy of Sciences SLSigrid A. LehnertCommonwealth Scientific and Industrial Research Organisation

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Implication

Experimental study reveals dynamic DNA methylation and demethylation during mouse embryogenesis, indicating distinct epigenetic programming across somatic and germline tissues.

Key Points

To characterize the timing and tissue-specific patterns of global DNA demethylation and de novo remethylation across embryonic, extraembryonic, and germline lineages during mouse development.
Assessed global genomic DNA methylation states in mouse gametes (sperm and egg), preimplantation embryos, postgastrulation embryonic tissues, extraembryonic structures, and fetal germ cells.
Egg genomes are markedly undermethylated compared to sperm genomes, followed by widespread loss of genomic methylation during preimplantation development.
Embryonic and extraembryonic somatic lineages undergo independent, progressive remethylation extending postgastrulation to reinforce lineage-specific gene expression and female X chromosome inactivation.
Fetal germ cell DNA remains markedly undermethylated throughout development, indicating the germ lineage separates before extensive somatic de novo methylation occurs.

Cite This Study

Monk et al. (1987) studied this question.

synapsesocial.com/papers/6a0cba260800615de17a67cc https://doi.org/10.1242/dev.99.3.371

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Implication

Experimental study reveals dynamic DNA methylation and demethylation during mouse embryogenesis, indicating distinct epigenetic programming across somatic and germline tissues.

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

Discussion

Member takes

Implication

Key Points

Cite This Study

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

Discussion

Member takes

Implication

Key Points

Cite This Study

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