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The review aims to provide a comprehensive understanding of the various therapeutic strategies for colon cancer and their mechanistic implications.

Comprehensive Overview of Therapeutic Strategies in Colon Cancer: Chemotherapy, Targeted Therapy, and Immunotherapy

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The review aims to provide a comprehensive understanding of the various therapeutic strategies for colon cancer and their mechanistic implications.
Analyzed conventional chemotherapy regimens like FOLFOX and FOLFIRI.
Examined molecularly targeted therapies, including RAS/RAF mutations and HER2 amplification.
Discussed immunotherapy approaches targeting PD-1/PD-L1 and explored resistance mechanisms.
Identified key driver alterations affecting therapeutic response.
Outlined combination strategies to address therapeutic resistance.
Presented emerging treatment modalities such as KRAS G12C inhibitors and AI-guided algorithms.

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This review synthesizes treatment strategies for colon cancer, indicating implications for precision therapy and resistance management.

Sulaiman et al. (2026) studied this question.

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