Drug hypersensitivity reactions in adults: clinical patterns and drug profile

Aims: Drug hypersensitivity reactions (DHRs) are immunologically mediated adverse drug reactions increasingly reported in recent years. This study aimed to assess the demographic characteristics and self-reported clinical features of adults presenting with suspected DHRs to two tertiary centers in Konya, Türkiye, and to examine the distribution of reactions attributed to β-lactam antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). Methods: This retrospective study included 138 patients who presented with suspected DHRs between 1 April and 30 October 2025 and had complete demographic and clinical data. Only reactions compatible with immunological mechanisms and occurring within the first 6 hours after drug intake were evaluated. Demographic variables, culprit drugs, reaction timing and type, and coexisting allergic diseases were extracted from electronic medical records.Results: The median age was 40 years, and 73.9% were female. Cutaneous manifestations were the predominant presentation (89.1%), and 65.9% of reactions occurred within the first hour. β-lactams (43.5%) and NSAIDs (40.6%) were the main implicated drugs. The anaphylaxis rate was 19.6%, and 69.6% required hospitalization. Reactions within the first hour were associated with higher rates of anaphylaxis (28.6% vs. 2.1%; p