Copper-catalyzed radical 1,2-oxysulfoximination of β,γunsaturated oximes for the synthesis of sulfoximine-substituted isoxazolines

Muthukrishnan Murugan; Kishor R. Thete; Vijay Vara; Raj Y Patel

doi:10.1039/d6ob00244g

January 1, 2025Organic & Biomolecular Chemistry

Copper-catalyzed radical 1,2-oxysulfoximination of β,γunsaturated oximes for the synthesis of sulfoximine-substituted isoxazolines

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Key Points

This research aims to explore a copper-catalyzed process for producing sulfoximine-substituted isoxazolines from unsaturated oximes.
Copper-catalyzed radical transformation
1,2-oxysulfoximination of beta-gamma-unsaturated oximes
Intramolecular iminoxyl radical cyclization
Interception with sulfoximines
Effective synthesis of sulfoximine-substituted isoxazolines
High efficiency in the radical transformation
Successful use of intramolecular mechanisms in synthesis

Implication

Copper-catalyzed transformation synthesizes sulfoximine-substituted isoxazolines, suggesting effective reactions.

Abstract

Herein, we report a copper-catalyzed radical 1,2oxysulfoximination of β,γ-unsaturated oximes. The transformation proceeds via intramolecular iminoxyl radical cyclization followed by interception with sulfoximines, enabling efficient access to sulfoximine-substituted isoxazolines in...

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Cite This Study

Murugan et al. (2025) studied this question.

synapsesocial.com/papers/69be37406e48c4981c676aef https://doi.org/10.1039/d6ob00244g

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Copper-catalyzed radical 1,2-oxysulfoximination of β,γunsaturated oximes for the synthesis of sulfoximine-substituted isoxazolines

Key Points

Implication

Abstract

Discussion

Cite This Study

Copper-catalyzed radical 1,2-oxysulfoximination of β,γunsaturated oximes for the synthesis of sulfoximine-substituted isoxazolines

Key Points

Implication

Abstract

Discussion

Cite This Study

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