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Research article demonstrates programmable RNA synthesis control using DNA flaps in a protein-free system, indicating new possibilities for genetic engineering.
A pyrimidine-rich DNA flap serves as a molecular brake that blocks transcription by T7 RNA polymerase. In Research Article (e20198), Ki Soo Park and co-workers report the programmable cleavage of the flap by DNAzymes or MNAzymes releases this brake and restores RNA synthesis. This strategy establishes a protein-free, sequence-programmable transcription platform enabling precise ON/OFF control of RNA synthesis.
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Lee et al. (2026) studied this question.
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