Answers are grounded in this paper and cite their sources.
Observational analysis associates NLRP3 activation with M2 macrophage polarization in colon cancer, suggesting immune suppression effects.
In patients with MSS-CRC, aberrant activation of NLRP3 immunosome was significantly associated with lymph node metastasis of tumors. It is also closely related to the polarization of M2 macrophages in the tumor microenvironment, and further affects the infiltration of CD8+T lymphocytes, thereby creating a suppressive immune microenvironment.
No takes yet. Share an insight, caveat, or question.
Lü et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: