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Pulecio et al. demonstrate how chromatin regions induce gene expression in embryonic stem cells, suggesting new differentiation techniques.
In briefPulecio et al. demonstrate that embryonic stem cells (ESCs) harbor activatable chromatin regions able to directly induce lineage gene expression, linking ESC chromatin state to developmental plasticity.These regions are preenhancers that exhibit unconventional signatures and can be harnessed to promote the direct conversion of ESCs into differentiated cell types.
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Pulecio et al. (2026) studied this question.
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