Randomized trial compares efficacy of hyaluronic acid and red platelet-rich fibrin in managing stage III periodontitis, suggesting significant improvements for both adjuncts.
Objective: This study aims to compare clinical efficacy of red injectable platelet-rich fibrin (i-PRF) and hyaluronic acid (HA) as adjuncts to professional mechanical plaque removal (PMPR) in non-surgical management of stage III periodontitis. Materials and Methods: 75 patients were split into groups: group one (G1) received HA, group two (G2) received red i-PRF, and group three (G3), received only PMPR. At the baseline, the fourth, eighth-, and twelfth weeks following treatment, the plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), and probing depth (PD) were all measured. Results: The plaque index, gingival index, and bleeding on probing were significantly improved in all groups. Moreover, the probing depth in all three groups displayed lower levels over the three months, with G1 and G2 experiencing the greatest declines. Additionally, G1 and G2 showed a considerable increase in clinical attachment level, while G3 showed no improvement. Conclusion: Thus, the application of HA and red i-PRF in conjunction with PMPR significantly improves all periodontal metrics, however, there is no statistically significant distinction between them.
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MAZLOUM et al. (2023) studied this question.
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