Case report shows tripe palms and acanthosis nigricans in gastric adenocarcinoma, suggesting early detection for better outcomes.
Introduction and importance: Tripe palms (TP) and acanthosis nigricans (AN) are rare paraneoplastic dermatoses strongly associated with underlying malignancies, particularly gastric and lung carcinoma. Here, we report a case highlighting this uncommon dermatological manifestation as a marker of gastric carcinoma. Case presentation: We report a case of 47-year-old man who presented with progressive hyperpigmented, hyperkeratotic cutaneous lesions consistent with TP and AN. Further evaluation revealed gastric adenocarcinoma with nodal metastasis, confirmed by histopathology and positron emission tomography - computed tomography. Following neoadjuvant chemotherapy and partial gastrectomy, he demonstrated both clinical and marked regression of cutaneous manifestations. Discussion: TP and AN may serve as early paraneoplastic markers. Conclusion: Early recognition of paraneoplastic cutaneous manifestation can provide an early clue to internal malignancy, warranting prompt evaluation and timely treatment for better outcomes.
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Budha et al. (2026) studied this question.
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