Demonstrates the formation of ring-fused quinazolinones in novel compounds, suggesting a new synthesis method for these structures.
N-(3-Methylbut-2-en-1-yl)quinazolin-4(3H)-ones were designed as new building skeletons for the construction of C2-sulfonamidylated pyrrolo-quinazolinones through photocatalytic cascade sulfonamidation/cyclization with N-sulfonylaminopyridinium salts. Meanwhile, C3-sulfonamidylated piperidino-quinazolinones were constructed using N-(4-methylpent-3-en-1-yl)quinazolin-4(3H)-ones as substrates. The significant feature of this methodology lies in the direct installation of sulfonamidyl into the pyrrolo/piperidino core rather than into the side chain.
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Pan et al. (2026) studied this question.
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