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Visible-light-driven radical amination and cyclization produces sulfonaminated quinolinoquinazolines under mild conditions, suggesting efficient synthesis methods.
A visible-light-driven radical amination/cyclization of arylethynyl quinazolin-4(3H)-ones was developed using N-aminopyridinium salts as sulfonamino radical precursors. A series of sulfonaminated quinolino[2,1-b]quinazolines were successfully synthesized under oxidant- and additive-free conditions. The transformation features a broad substrate scope, good to excellent yields, and mild reaction conditions. Notably, the amination-cyclization reaction could proceed smoothly under natural sunlight irradiation.
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Liu et al. (2026) studied this question.
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