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The aim is to review how genetic polymorphisms influence the pharmacokinetics and toxicokinetics of carbamazepine.

March 21, 2026Vojnosanitetski pregledOpen Access

Genetic polymorphism and pharmacokinetics/toxicokinetics of carbamazepine: A general review

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The aim is to review how genetic polymorphisms influence the pharmacokinetics and toxicokinetics of carbamazepine.
Comprehensive analysis of genetic impacts on carbamazepine metabolism.
Review of cytochrome P450 enzyme roles in drug metabolism.
Examination of transporter polymorphisms and their effects on drug exposure.
Genetic polymorphisms in CYP enzymes and transporters significantly alter carbamazepine metabolism.
Saturable epoxidation leads to unpredictable toxicity during overdose events.
Therapeutic drug monitoring and pharmacogenetic testing can enhance treatment efficacy and safety.

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Review discusses how genetic factors impact carbamazepine pharmacokinetics in various conditions, suggesting individualized treatment approaches.

Kovacevic et al. (2026) studied this question.

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Review discusses how genetic factors impact carbamazepine pharmacokinetics in various conditions, suggesting individualized treatment approaches.