Research demonstrates a palladium-catalyzed synthesis of isoquinolinones, indicating a new carbonylation method for bioactive compounds.
We report a palladium-catalyzed carbonylative synthesis of alkynone-substituted isoquinolinones utilizing chloroform as a safe CO surrogate. The base-mediated hydrolysis of CHCl₃ generates CO in situ, facilitating the efficient coupling of 2-iodobenzamides with alkynes. Furthermore, this external CO-free protocol demonstrates a broad substrate scope, excellent functional group tolerance, and scalability, thereby providing direct access to bioactive isoquinoline scaffolds.
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Li et al. (2026) studied this question.
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